Изучено влияние дииндолилметана в дозе 600 мг/кг на изменение “силы” сцепления альвеоцитов и гепатоцитов мышей линии CBA. Дииндолилметан вводили животным опытной группы внутрижелудочно в течение 10 сут, контрольная группа получала физиологический раствор в аналогичном объеме и режиме. По завершении терапевтического периода у мышей, получавших дииндолилметан, выявлено статистически значимое увеличение силы сцепления альвеоцитов на 16% (р=0.003) и гепатоцитов на 61% (р=0.0001) по сравнению с контрольной группой, что свидетельствует об антипромоторной активности дииндолилметана.

In this research influence of diindolylmethane in a dosage of 600 mg/kg on change of force of adhesion of alveotsit and hepatocytes of mice of the CBA line has been studied. Animals has been in a random way distributed in one of three studied groups study (contains 20 mices) or control (contains 20 mices), and 10 in intact group. Diindolilmetan was entered by an animal of skilled group daily, intragastric for 10 days, the control group received physiological solution in the similar volume, a way of introduction and duration. At the end of the therapeutic period animals have undergone euthanasia, with the subsequent harvesting and the analysis of tissues of liver and lungs. As a result of material studying, in skilled group statistically significant increase in force of adhesion of alveotsit by 16% (р = 0,0026) and hepatocytes for 62% (р =0,0001) in comparison with control group of the animals receiving physiological solution that shows anti-pro-motor activity of diindolylmethane is revealed.