Фармакология и токсикология
Нейропротективное действие метиленового синего in vivo и in vitro
Ключевые слова: черепно-мозговая травма, метиленовый синий, нейроны, паракват, ионы цинка
Neuroprotective effects of methylene blue in vivo and in vitro
Focal unilateral traumatic brain injury in the sensorimotor cortical region disturbed the functions of contralateral limbs controlled by the damaged hemisphere. A single intravenous injection of methylene blue (1 mg/kg) immediately before or 30 min after the injury significantly weakened functional disorders in the affected extremities. In vitro experiments showed that methylene blue effectively reduced death of cultured neurons provoked by paraquat or zinc ions producing the toxic effects on mitochondrias.